The safety of cosmetic products is constantly in question as the components are always changing or being discovered as a possibly harmful substance. The sulfite components of cosmetic ingredients, such as sodium bisulfite, underwent clinical trials to find out their safety in cosmetic formulations. Sodium bisulfite functions as a reducing agent and furthermore as a hair-waiving/straightening agent.[8] As of 1998, sodium bisulfite was used in 58 different cosmetic products including hair conditioners, moisturizers, and hair dyes.[9] In a cosmetic context, the reducing ability of sodium bisulfite is used to prevent discoloration, bleach food starches, and delay spoilage of the product. Since the sulfite molecule was used in so many compounds in the 1990s, the EPA, FDA, and American Conference of Governmental Industrial Hygienists established a working place threshold limit value for sulfur dioxide of 2ppm averaged over 8 hours, and a 3-hour level of 5ppm. Even with this threshold established, the FDA recognized sodium bisulfite as a "generally recognized as safe" compound.[3] A final examination on the carcinogenicity, genotoxicity, oral toxicity, and cellular toxicity on consumed sodium bisulfite was conducted using living subjects such as mice and rats. The International Agency for Research on Cancer concluded that there was inadequate evidence that sodium bisulfite was carcinogenic.[3] Under specific conditions such as acidity and concentration level, sodium bisulfite was able to cause negative alterations to the genome such as catalyzing transamination, and induce sister-chromatid exchanges suggesting possible genotoxicity.[10] In a study using Osbourne-Mendel strain rats, it was concluded that oral toxicity was not significant if the consumed concentration was less than 0.1% (615ppm as SO2).[11] A study done by Servalli, Lear, and Cottree in 1984 found that sodium bisulfite did not produce membrane fusion in hepatic and murine glial cells and human fibroblasts so there is no oral toxicity. These clinical studies concluded that sodium bisulfite was safe to use in cosmetic formulations.[3]