Pyridoxine (PN)[4] is a form of vitamin B6 found commonly in food and used as a dietary supplement. As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects or complications of isoniazid use, and certain types of mushroom poisoning.[5] It is used by mouth or by injection.[5] It is usually well tolerated.[5] Occasionally side effects include headache, numbness, and sleepiness.[5] Normal doses are safe during pregnancy and breastfeeding.[5] Pyridoxine is in the vitamin B family of vitamins.[5] It is required by the body to metabolise amino acids, carbohydrates, and lipids.[5] Sources in the diet include fruit, vegetables, and grain.[6] Medical uses As a treatment (oral or injection), it is used to treat or prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects of isoniazid treatment and certain types of mushroom poisoning.[5] Isoniazid is an antibiotic used for the treatment of tuberculosis. Common side effect include numbness in the hands and feet.[7] Co-treatment with vitamin B6 alleviates the numbness.[8] Pyridoxine-dependent epilepsy is a type of rare infant epilepsy that does not improve with typical anti-seizure medications.[9] Pyridoxine in combination with doxylamine is used as a treatment for morning sickness in pregnant women.[